Are you thinking of advancing your IV therapy medical practice but still unsure if this is right for you? We understand where you are coming from, which is why we share 3 reasons why you should consider adding intravenous (IV) therapy to your skillset.

If you also want to start your own IV therapy business but are uncertain about what protocols to use, then we got you covered. This article will tackle the top 5 IV protocols used by every well-established clinic and some studies that support their use. These protocols become especially important if you want to kick start your IV practice. But if you want a head start, watch our free masterclass on how to open one and overcome scope of practice limitations.

Myers cocktail

“Myers’ cocktail” may be synonymous with IV micronutrient therapy (IVMT) to some since this infusion started it all. Dr. John Myers pioneered the use of IV vitamins and minerals to treat his patients with a variety of medical problems since the late 1950s. His patients, who have been taking IV therapy for decades, attest to its effectiveness and even seek it long after he died. Current knowledge caused modifications to enhance the original concoction made by Dr. Myers, but it remains the most popular IV protocol.

In a review of Dr.Gaby, the modified version was beneficial for a wide range of medical conditions, time and again with outstanding results. It is often best for health issues such as asthma, migraines, fatigue, fibromyalgia, muscle spasm, upper respiratory tract infection, and inflammation. Even relatively healthy patients chose to receive it because it enhances their overall well-being.

The common components of Myers Cocktail include magnesium, calcium, vitamin B complex, and vitamin C. These are known to support the immune system, promote bone health and help relieve pain and inflammation. These nutrients' effects are dose-dependent and can only be achieved with IV therapy, not through oral supplements. Several studies support these limitations. Check out our article regarding the use of vitamin C in cancer.

Perfect dosage combination is the key in any IV protocol considering that vitamin C’s antiviral and antihistamine effect can manifest only upon reaching a certain serum level. Magnesium relaxes both vascular and bronchial smooth muscle that aids those suffering from vasospasm and bronchial asthma. It can also potentially improve mood and enhance the effects of standard antidepressant treatment, as confirmed by a study in 2016.

Aside from the clinical support of calcium supplementation to bone health, early research demonstrated its promising effect on acute asthma exacerbations and severe anaphylactic reactions. More so, certain combinations of vitamin B not only prevent and treat deficiency but also influence one's energy levels, brain function, and cell health.

A trial conducted on the use of Myers' cocktail for patients with fibromyalgia syndrome (FMS) established the safety and feasibility of treatment with IV therapy. Most subjects experienced relief compared to baseline with clinically significant improvements, though bigger sample size is required to cement the results. Given the high rate of dehydration in fibromyalgia patients, we can count on the benefits the infusion will bring.

MIC/Skinny Shot

MIC stands for methionine, inositol, and choline. Together with carnitine, B6, and B12, this blend helps the body's metabolism, removes toxins, and promotes fat loss. It speeds up fat burning and assists in weight loss while providing energy support.

Each component of Lipo (MIC) Injection delivers an effect, though the combination may prove synergistic. Choline, together with myoinositol supplements can inhibit weight gain while decreasing liver fat. Methionine can regulate metabolic processes digestive function and affects lipid metabolism too. Meanwhile, inositol accelerates weight loss and fat mass reduction while increasing lean mass. It can also exhibit medical benefits in patients with diabetes and hypertension.

A study on choline supplementation use resulted in rapidly reduced body mass for female athletes and improved lipid metabolism without any side effects on strength. Furthermore, a significant reduction in the urine malondialdehyde (MDA) was observed, proving choline’s use as an antioxidant. Several studies support that L carnitine can significantly decrease body mass index (BMI) and have numerous cardiovascular benefits. Overall, this IV protocol not only promotes a leaner body but a healthier one as well.

Glutathione Infusion

Glutathione (GSH) is a small protein found in cells and is a master antioxidant that enhances the utilization and recycling of other antioxidants. It comprises three amino acids: cysteine, glycine, and glutamate. You can find it in foods such as spinach, avocados, asparagus, okra, etc., although cooking and pasteurization diminish its levels significantly.

GSH’s value as a nutritional supplement derives from its role in synthesizing proteins in the body. These proteins perform many functions relating to the synthesis and repair of tissues. Although, its primary use is still an antioxidant that prevents or slows down the damage caused by free radicals. As numerous bodily functions can create free radicals, damage caused by it starts to add up, causing what is known as oxidative stress.

Heart disease, cancer, diabetes, arthritis, and other inflammatory conditions are all linked to oxidative stress that could be neutralized by an antioxidant. As we age, our body’s Glutathione level naturally declines. Although this can be produced in the body (endogenous antioxidant), supplementation and following healthy lifestyle practices are important. The body’s demand for glutathione increases in times of immense stress – illness, injury, or infection (such as a global pandemic).

Since it is involved in many biological processes – free radical neutralization, detoxification, vitamin C and E regeneration, etc. – IV therapy Glutathione can support the immune system, aid in healing, and recovery, while helping your skin glow. GSH demonstrates a protective role towards all cells (brain, heart, liver, kidneys, lungs, etc), supporting cancer treatment and reproductive health. It even manifested benefits in the treatment of COVID-19.

Aside from its influence on a couple of medical conditions, GSH level also affects the skin and apparent signs of aging. In a 2017 study, subjects supplemented with GSH showed a significant reduction in wrinkles and increased skin elasticity compared to placebo treatments. Another study on females with brown or dark brown skin established that it is safe and effective in lightening the skin. This was further supported by Duperray in a 2021 study validating the lightening of skin coupled with the reduction of facial dark spot size.

A novel wound dressing incorporated with GSH accelerated the healing process by 70%. Combined with copper ions, another study explored the antimicrobial and wound healing potential of glutathione against multidrug-resistant (MDR) bacterial infections, where it prevented postsurgical wound infections and aided in wound closure. These are just some of the many undergoing research regarding this antioxidant's use and endless potential, GSH.

Athletic Performance Roadrunner

Athletic performance and recovery can be supported by a blend of Amino Acids, Vitamin B-Complex, Normal Saline, and Antioxidants (glutathione and α-lipoic acid). Each contributes to increasing physical performance, aiding recovery, improving activity tolerance, and replenishing fluids and nutrients. Lower levels of dehydration can diminish the body's capabilities emphasizing the need for sufficient fluid intake. Aside from that, replenishment of lost nutrients can prove instrumental in keeping up with strenuous activities.

Aerobic muscular endurance can be increased significantly with the supplementation of amino acids. It can delay exhaustion time during exercise or activity and aids in improving grip and leg strength while decreasing body weight and fat mass. These effects are further enhanced with the use of Vitamin B-complex.

According to a study, antioxidant supplementation before intensive exercise may improve physical performance. It increases time to fatigue and recovery from exercise. In a randomized trial on 75 resistance-trained males, supplementation of GSH with L-citrulline (CIT) increased lean mass and muscle strength. Intake of α-lipoic acid (ALA) may prove helpful to enhance skeletal muscle regeneration because of changes it generates in the inflammatory response.

Immunity Booster with Hydration

The immune system protects us against harmful microbes as well as certain diseases. Whether innate (protective barriers) or adaptive (also known as acquired) immunity, a deficiency of nutrients can alter the body's immune response. Due to this, the role of hydration and nutrition in immunity has received increasing attention. A combination of fluids, Vitamin C, Zinc, Glutathione, Magnesium, and B-complex can help boost one's response to diseases. This IV protocol can guard and strengthen the body, support wound therapy and promote general health.

Zinc is recognized to have wide-range effects on immunity. It is needed for the normal development and success of cells mediating nonspecific and acquired immunity. It plays an important part in the growth of cells, building proteins, and healing damaged tissues. It may reduce inflammation, even improving lung clearance.

Zinc also functions as an antioxidant that stabilizes membranes and prevents apoptosis or cell death. A review of current data suggests that adequate zinc level increases immune reactivity and modulates antiviral and antibacterial immunity. Thus, inadequate supply may predispose an individual to infectious diseases such as the upper and lower respiratory tract.

Same as Zinc, Magnesium, and Vitamin C also support various aspects of innate and adaptive immune systems. Deficiency in Vitamin C has been associated with impairments in immunity and increased susceptibility to more infections. It is also known to reduce the severity and shorten the duration of cold symptoms. Likewise, magnesium deficit has impaired cellular and humoral immune function, delaying the sequential inflammatory response.

Damage from free radicals can impair bodily functions, thus the need for antioxidants. Insufficient levels of Glutathione have a profound influence on weakening the immune system, so the body’s ability to fight infections is lessened. Vitamin B-complex also plays a role in decreasing oxidative stress, acting as an antioxidant. At the same time, it is vital on several immune processes, such as lessening inflammation and improving pulmonary function while exhibiting anti-stress effects and lowering anxiety.

Important to note

Whether helping in the treatment of various medical conditions (cancer, infection, fatigue, inflammation, etc.), improving health and total body performance, or giving an immune boost, individualized prescriptions to fit each clients’ nutritional and physiological needs are advised.

Remember that vitamin and mineral supplements should not be considered a substitute for a good diet and healthy lifestyle. Still, proper IV infusion of a professional IV therapy provider can bring about benefits that can improve one's way of life. It is imperative to strictly follow IV protocol's proper storage, infusion, and dosing to prevent any untoward complications.

The use of IV therapy for support and treatment has been around for decades. Clinical results have been presented in conferences, and several studies were conducted regarding its potential benefits; however, most of these are preclinical, with small sample size. As the quest for new knowledge and the need for alternative medicine still stands, we can look forward to more fresh insight regarding these treatments.

Reference:

Abobaker, A., Alzwi, A., & Alraied, A. H. A. (2020). Overview of the possible role of vitamin C in management of COVID-19. Pharmacological Reports, 72(6), 1517-1528.

Ali, A., Njike, V. Y., Northrup, V., Sabina, A. B., Williams, A. L., Liberti, L. S., ... & Katz, D. L. (2009). Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study. The Journal of Alternative and Complementary Medicine, 15(3), 247-257.

Antonio, J., Sanders, M. S., Ehler, L. A., Uelmen, J., Raether, J. B., & Stout, J. R. (2000). Effects of exercise training and amino-acid supplementation on body composition and physical performance in untrained women. Nutrition, 16(11-12), 1043-1046.

Azhar, G., Wei, J. Y., Schutzler, S. E., Coker, K., Gibson, R. V., Kirby, M. F., ... & Wolfe, R. R. (2021). Daily consumption of a specially formulated essential amino acid-based dietary supplement improves physical performance in older adults with low physical functioning. The Journals of Gerontology: Series A, 76(7), 1184-1191.

Babar, Q., Ali, A., Saeed, A., & Tahir, M. F. (2021). Novel Treatment Strategy against COVID-19 through Anti-Inflammatory, Antioxidant and Immunostimulatory Properties of the B Vitamin Complex.

Duperray, J., Sergheraert, R., Chalothorn, K., Tachalerdmanee, P., & Perin, F. (2021). The effects of the oral supplementation of L‐Cystine associated with reduced L‐Glutathione‐GSH on human skin pigmentation: a randomized, double‐blinded, benchmark‐and placebo‐controlled clinical trial. Journal of Cosmetic Dermatology.

Elsawy, G., Abdelrahman, O., & Hamza, A. (2014). Effect of choline supplementation on rapid weight loss and biochemical variables among female taekwondo and judo athletes. Journal of human kinetics, 40, 77–82. https://doi.org/10.2478/hukin-2014-0009

Foresman, G. E. IV Nutrition Therapy–Myers’ Cocktail.

Gaby, A. R. (2002). Intravenous nutrient therapy: the" Myers' cocktail". Alternative Medicine Review, 7(5), 389-403.

Grootswagers, P., Mensink, M., Berendsen, A. A., Deen, C. P., Kema, I. P., Bakker, S. J., ... & de Groot, L. C. (2021). Vitamin B-6 intake is related to physical performance in European older adults: Results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study. The American journal of clinical nutrition, 113(4), 781-789.

Handog, E. B., Datuin, M. S., & Singzon, I. A. (2016). An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women. International journal of dermatology, 55(2), 153–157. https://doi.org/10.1111/ijd.12999

Hwang, P., Morales Marroquín, F.E., Gann, J. et al. Eight weeks of resistance training in conjunction with glutathione and L-Citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained males. J Int Soc Sports Nutr 15, 30 (2018). https://doi.org/10.1186/s12970-018-0235-x

Jafari D., Esmaeilzadeh A., Mohammadi-Kordkhayli M., Rezaei N. (2019) Vitamin C and the Immune System. In: Mahmoudi M., Rezaei N. (eds) Nutrition and Immunity. Springer, Cham. https://doi.org/10.1007/978-3-030-16073-9_5

Julius, M., Lang, C. A., Gleiberman, L., Harburg, E., DiFranceisco, W., & Schork, A. (1994). Glutathione and morbidity in a community-based sample of elderly. Journal of clinical epidemiology, 47(9), 1021–1026. https://doi.org/10.1016/0895-4356(94)90117-1

Kenney, J. L., & Carlberg, K. A. (1995). The effect of choline and myo-inositol on liver and carcass fat levels in aerobically trained rats. International journal of sports medicine, 16(2), 114–116. https://doi.org/10.1055/s-2007-972975

Laires, M. J., & Monteiro, C. (2008). Exercise, magnesium and immune function. Magnes Res, 21.

Le Donne, M., Metro, D., Alibrandi, A., Papa, M., & Benvenga, S. (2019). Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome. European review for medical and pharmacological sciences, 23(5), 2293–2301. https://doi.org/10.26355/eurrev_201903_17278

Mach J, Midgley AW, Dank S, Grant RS, Bentley DJ. The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H). Nutrients. 2010; 2(3):319-329. https://doi.org/10.3390/nu2030319

Martínez, Y., Li, X., Liu, G., Bin, P., Yan, W., Más, D., Valdivié, M., Hu, C. A., Ren, W., & Yin, Y. (2017). The role of methionine on metabolism, oxidative stress, and diseases. Amino acids, 49(12), 2091–2098. https://doi.org/10.1007/s00726-017-2494-2

Pooyandjoo, M., Nouhi, M., Shab‐Bidar, S., Djafarian, K., & Olyaeemanesh, A. (2016). The effect of (L‐) carnitine on weight loss in adults: a systematic review and meta‐analysis of randomized controlled trials. Obesity reviews, 17(10), 970-976.

Sen, S., & Sarkar, K. (2021). Effective biocidal and wound healing cogency of biocompatible glutathione: citrate-capped copper oxide nanoparticles against multidrug-resistant pathogenic enterobacteria. Microbial Drug Resistance, 27(5), 616-627.

Serefko, A., Szopa, A., & Poleszak, E. (2016). Magnesium and depression. Magnesium research, 29(3), 112-119.

Shankar, A. H., & Prasad, A. S. (1998). Zinc and immune function: the biological basis of altered resistance to infection. The American journal of clinical nutrition, 68(2 Suppl), 447S–463S. https://doi.org/10.1093/ajcn/68.2.447S

Skalny, A. V., Rink, L., Ajsuvakova, O. P., Aschner, M., Gritsenko, V. A., Alekseenko, S. I., ... & Tinkov, A. A. (2020). Zinc and respiratory tract infections: Perspectives for COVID‑19. International journal of molecular medicine, 46(1), 17-26.

Soleimani, D., Miryan, M., Hadi, V., Gholizadeh Navashenaq, J., Moludi, J., Sayedi, S. M., ... & Hadi, S. (2021). Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: A triple‐blind randomized clinical trial. Food Science & Nutrition.

Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, cosmetic and investigational dermatology, 10, 147–153. https://doi.org/10.2147/CCID.S128339

Zembron-Lacny, A., Gajewski, M., Naczk, M., Dziewiecka, H., & Siatkowski, I. (2013). Physical activity and alpha-lipoic acid modulate inflammatory response through changes in thiol redox status. Journal of physiology and biochemistry, 69(3), 397-404.